Natalya Y Abramycheva

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BACKGROUND Brain dysfunction precedes clinical manifestation of Huntington's disease (HD) by decades. This study was aimed to determine whether resting EEG is altered in preclinical HD mutations carriers (pre-HD). METHODS We examined relative power of broad traditional EEG bands as well as 1-Hz sub-bands of theta and alpha from the resting-state EEG of 29(More)
The concentration dependences of the binding of fusicoccins (FCs) A, B, C, D, J and H to plasma membranes isolated from maize (Zea mays L.) roots have been studied in parallel with the effects of these compounds on elongation and 86Rb transport in detached maize roots. The dissociation constants obtained showed a good correlation between the affinity of the(More)
Cohorts of amyotrophic lateral sclerosis (ALS) patients and control individuals of Caucasian origin from the Central European Russia (Moscow city and region) were analyzed for the presence of hexanucleotide repeat GGGGCC expansion within the first intron of the C9ORF72 gene. The presence of a large (>40) repeat expansion was found in 15% of familial ALS(More)
A 5-kb region of theAcholeplasma laidlawii PG-8B genome was sequenced. The region contained the genes for RecF, DNA gyrase subunits A and B (GyrA and GyrB), and a fragment of the ATP-binding subunit of the hypothetical ABC transporter. In phylogenetic analysis,A. laidlawii GyrA and GyrB formed statistically significant, stable clusters with the(More)
Molecular modeling is a promising method for assessing protein structures that is capable of presenting an energetically beneficial protein conformation with atomic precision. This method is of great importance for studying molecular interactions and confirming the pathogenic significance of the changes in protein structures caused by particular mutations.(More)
Our review is focused on new aspects of the pathogenesis of amyotrophic lateral sclerosis (ALS); it considers the hypothesis that disturbances in transcription have a substantial role in ALS. We described the functions of ALS-related genes whose protein products are involved in various processes of mRNA metabolism. We present modern concepts on the(More)
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