Natalya V Ponomareva

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The application of DC-potential method for estimation of the rate of human brain energy metabolism opens new vistas for the development of theoretical and applied aspects of neurophysiology. Theoretically, the close connection of information and energy processes of the brain is essential for gaining an insight into the brain energy-formation unit. In(More)
Polymorphism in the genomic region harboring the CLU gene (rs11136000) has been associated with the risk for Alzheimer's disease (AD). CLU C allele is assumed to confer risk for AD and the allele T may have a protective effect. We investigated the influence of the AD-associated CLU genotype on a common neurophysiological trait of brain activity(More)
Identification of preclinical markers is required for early diagnosis of Alzheimer's disease (AD) and cognitive dysfunction in advancing age. Quantitative EEG was examined in 145 individuals with AD, their unaffected relatives and unrelated individuals. The AD patients and their relatives were stratified by ApoE genotype. The resting EEG parameters were(More)
A total of 160 patients with Alzheimer-type dementias (ATD), including 84 with Alzheimer's diseases (AD) and 76 with senile dementia (SD), were examined. The initial signs of the disease were analyzed by making a retrospective assessment of informative history data. The prospective follow-up involved clinical, neuropsychological and electrophysiological(More)
In normal aging and Alzheimer's disease, there are regular changes in brain energy homeostasis, which are associated both with the time course of the average level of catabolism and with the intensity rate of catabolic processes by hemispheres. In normal aging, there is generally decrease in the catabolic level estimated by the level of the DC potential. In(More)
Twenty first-order relatives of patients with early-onset Alzheimer's disease (AD; mean age 43.7 +/- 1.3 years), 20 patients with early-onset AD (mean age 65.7 +/- 0.9 years) and age-matched normal controls for the relatives and the patients underwent quantitative EEG (qEEG) examinations. In AD patients, delta and theta relative power values were increased(More)
Visual-evoked potentials (VEP) to a flash were studied in the first-order relatives of patients with Alzheimer's disease (AD) (mean age 38.2 +/- 2.6 years) in comparison with the patients (mean age 61.9 +/- 1.4 years) and age-matched normal controls. It was found that in the relatives of AD patients the latencies of N2, P3, N3 components were delayed(More)
BACKGROUND Brain dysfunction precedes clinical manifestation of Huntington's disease (HD) by decades. This study was aimed to determine whether resting EEG is altered in preclinical HD mutations carriers (pre-HD). METHODS We examined relative power of broad traditional EEG bands as well as 1-Hz sub-bands of theta and alpha from the resting-state EEG of 29(More)
The epsilon4 allele of the apolipoprotein E gene (ApoE), as well as aging increase the risk of Alzheimer's and vascular diseases. Electroencephalogram (EEG) reactivity to hyperventilation (HV) depends on hypocapnia-induced cerebral vasoconstriction, which may be impaired in subjects with subclinical cerebrovascular disease. Quantitative EEG at rest and(More)