Sort by:

• Highly Influential Citations
• Citations
• Acceleration
• Velocity
• Recency

Learn More

Identification of sites in adenovirus hexon for foreign peptide incorporation.

• Hongju Wu, Tie Yan Han, +6 authors David Curiel
• Journal of virology
• 2005

Adenovirus type 5 (Ad5) is one of the most promising vectors for gene therapy applications. Genetic engineering of Ad5 capsid proteins has been employed to redirect vector tropism, to enhance… (More)

Modulation of adenovirus vector tropism via incorporation of polypeptide ligands into the fiber protein.

• Natalya Belousova, Valentina Krendelchtchikova, David Curiel, Victor N. Krasnykh
• Journal of virology
• 2002

The efficacy of adenovirus (Ad)-based gene therapy might be significantly improved if viral vectors capable of tissue-specific gene delivery could be developed. Previous attempts to genetically… (More)

In vivo analysis of a genetically modified adenoviral vector targeted to human CD40 using a novel transient transgenic model.

• Miiru Izumi, Yosuke Kawakami, +8 authors David Curiel
• The journal of gene medicine
• 2005

BACKGROUND Retargeting is necessary to overcome the limitations of adenovirus (Ad)-based gene therapy vectors. To this end, we previously constructed an adenovirus with the fiber knob domain replaced… (More)

Targeting of adenovirus via genetic modification of the viral capsid combined with a protein bridge.

• Nikolay Korokhov, Galina V Mikheeva, +14 authors Victor N. Krasnykh
• Journal of virology
• 2003

A potential barrier to the development of genetically targeted adenovirus (Ad) vectors for cell-specific delivery of gene therapeutics lies in the fact that several types of targeting protein ligands… (More)

Genetically targeted adenovirus vector directed to CD40-expressing cells.

• Natalya Belousova, Nikolay Korokhov, +8 authors Victor N. Krasnykh
• Journal of virology
• 2003

The success of gene therapy depends on the specificity of transgene delivery by therapeutic vectors. The present study describes the use of an adenovirus (Ad) fiber replacement strategy for genetic… (More)

Optimization of capsid-incorporated antigens for a novel adenovirus vaccine approach

• Q. Matthews, Pingar Yang, +10 authors David Curiel
• Virology Journal
• 2008

Despite the many potential advantages of Ad vectors for vaccine application, the full utility of current Ad vaccines may be limited by the host anti-vector immune response. Direct incorporation of… (More)

Her2-specific multivalent adapters confer designed tropism to adenovirus for gene targeting.

• Birgit Dreier, Galina V Mikheeva, +6 authors Victor N. Krasnykh
• Journal of molecular biology
• 2011

Adenoviruses (Ads) hold great promise as gene vectors for diagnostic or therapeutic applications. The native tropism of Ads must be modified to achieve disease site-specific gene delivery by Ad… (More)

Development of a generic adenovirus delivery system based on structure-guided design of bispecific trimeric DARPin adapters.

• Birgit Dreier, Annemarie Honegger, +7 authors Andreas Plückthun
• Proceedings of the National Academy of Sciences…
• 2013

Adenoviruses (Ads) have shown promise as vectors for gene delivery in clinical trials. Efficient viral targeting to a tissue of choice requires both ablation of the virus' original tropism and… (More)

Circumventing recombination events encountered with production of a clinical-grade adenoviral vector with a double-expression cassette.

• Natalya Belousova, Raymond C. Harris, +8 authors Ronald D. Alvarez
• Molecular pharmacology
• 2006

Delivery of multiple exogenous genes into target cells is important for a broad range of gene therapy applications, including combined therapeutic gene expression and noninvasive imaging. Previous… (More)

[Treatment of dysentery in children with Pentoxyl in combination with antibacterial preparations].

• O V Cherkasov, Natalya Belousova, P O Blavdzevich
• Pediatriia akusherstvo i ginekologiia
• 1966

• ‹
• 1
• 2
• 3
• 4
• ›