Natalya A. Korotkova

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We revealed some relationships between the level of orientation and exploratory behavior, functional activity of the immune system, and structural and functional organization of the CNS in animals. Significant differences in brain morphology and expression of cytokine IL-1β, type I IL-1 receptor, and erythropoietin receptor genes in brain cells were(More)
Intravenous injection of adherent splenocyte fraction from donor (CBA×C57Bl/6)F1 mice characterized by specific open-field behavior modified this behavior in syngeneic recipient mice. This was paralleled by appropriate changes in the levels of IL-1β and type 1 IL-1 receptor mRNA in the brain cells of recipient mice. Hence, we demonstrated the possibility of(More)
We revealed a modulating effect of cell immune response on exploratory activity of (CBA°C57Bl/6)F1 mice depending on their initial behavioral profile. The formation of BCG-induced delayed-type hypersensitivity was accompanied by stimulation of the exploratory behavior in animals with initially low or intermediate activity, but did not change this parameter(More)
The present investigation develops a previously published concept on integration of the immune, endocrine, and nervous systems in a universal structural and functional block (IMEN system). Splenocytes from donor (CBA×C57Bl/6)F1 mice characterized by specific behavior in the open field test modified the behavior of syngeneic recipient mice after intravenous(More)
Now there is a growing evidence that erythropoietin receptors (Epo-R) are present also in some nonhematopoietic tissues such as endothelial cells and fetal cells of neural origin, although the physiological role of Epo-R at these sites is unclear. There are some speculations that Epo-R may be expressed on cells only in the developing CNS. The objective of(More)
Tissue-specific immune reactions were used to develop a method of dealing with malignant tumors. Injection of proteins isolated from lung tissue of mice (CBAxC57BL/6)F1, of varying age, into mice Balb/c with urethane-induced lung tumors cut the number of such tumors by half. Direct correlation was found between the magnitude and nature of effect and level(More)