Nataly Kravchenko

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The literature data concerning structure of cyclo-oxigenase-1--the key enzyme in prostaglandin biosynthesis and the main target of anti-platelet therapy with the use of acetylsalicilic acid are presented in the review. The data on cyclooxigenase-1 gene polymorphism, distribution of the revealed variants in various populations and their possible correlation(More)
Nitric oxide (NO) is formed from L-arginine by means of endothelial NO-synthase (eNOS). NO participates in regulation of physiologically important functions of the cardiovascular system (it regulates the contractive reduction of heart, cell proliferation, vascular tension, and blood pressure) and the immune and nervous systems. NO synthesis varies in(More)
A functional completeness of summing amplifier with saturation in a multi-valued logic of an arbitrary value proven in previous works gives a theoretical background for analog implementation of fuzzy devices. Practical design techniques for multi-valued analog fuzzy controllers still have to be developed. Compared with the traditional approach, analog CMOS(More)
PPARs play a key role in energy homeostasis, inflammation, development of insulin resistance, and the metabolic syndrome. Therefore, special attention is paid to the synthesis of PPAR ligands (fibrates, thiazolidinediones). Three isoforms of PPARs are activated by fatty acids and their derivatives—eicosanoids. The Pro12Ala polymorphism of the PPARG2 gene is(More)
A lysozyme-like enzyme isolated from the culture broth of Staph. aureus 712 presented in its native state a lipoproteid complex. The lytic and antibacterial spectrum of the enzyme was similar to that of the egg albumin enzyme. However, the lipoproteid complex was somewhat superior to the egg albumin complex in its activity against Micrococcus lysodeikticus,(More)
The thermostability and thermodinamics of formation of the enzyme-substrate complex of two oxidation products of chicken egg lysozyme with the tryptophane-62 residue modified to N'-formylkinurenine (with 2.5% activity) and kinurenine (with 27.5% activity) have been studied. In thermostability and pH effect on the substrate binding the lysozyme oxidation(More)