Natalija Tumanova

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The use of macromolecular adhesion factors (MAF) as a molecular tool made it possible to establish that at least two molecular mechanisms of cell adhesion are violated in the livers of mice genetically predisposed to spontaneous hepatoblastomogenesis in the late embryonic stages and during the early postnatal period. The biological effect of MAF on the(More)
Histological changes arising in the liver in chronic diseases may be associated with disturbances of intercellular relations between hepatocytes. Electron-microscopic investigations have shown that during cholestasis in patients with primary biliary cirrhosis, partial or total separation of the hepatocytes takes place, and leads to an increase in the(More)
Macromolecular adhesion factors have been obtained which differed from the previously obtained ones. They are acidic glycoconjugates with the molecular mass about 20-40 kD, which are capable of forming macromolecular aggregates and are located in the periphery of cell surface. After subdivision and purification of the mouse liver extract two-adhesion-active(More)
The influence of the extra-low dozes of the macromolecular adhesive factors (MAF) on the protein synthesis and on the ATP contents in the rat hepatocytes on different models in vitro has been investigated. The protein synthesis intensity, the cell penetrability for labelled 3H-leucine and the intracell ATP contents in the experiments with the hepatocyte(More)
We consider a predictor-corrector type finite difference scheme for solving one-dimensional parabolic problems. This algorithm decouples computations on different subdomains and thus can be efficiently implemented on parallel computers and used to solve problems on graph structures. The stability and convergence of the discrete solution is proved in the(More)
The method of man hepatobioptate study based on the change of cell adhesion is suggested to diagnose cholestatic syndrome. The quantitative assessment of cell adhesion in the liver was carried out with disconnected coefficient estimated as ratio of the quantity of single cells. Eight groups of patients suffering from chronic hepatic pathologies were(More)
The paper gives a review of the data available in the literature and an analysis of the authors' own data of the ultrastructural studies of the intercellular contacts of hepatocytes and epitheliocytes in some pathological states. It also shows an important role of the site of an element compound wherein the major molecular mechanisms of tissue homeostatic(More)
We consider one applied global optimization problem where a set of feasible solutions is discrete and very large. The goal is to find optimal perfect gratings, which can guarantee high quality and security of the visual cryptography method. A priori estimation techniques, such as branch and bound type methods, cannot be applied to exclude an essential part(More)
Disturbance of adhesive interactions between cells is observed in the course of various pathological processes, including those connected with invasive growth [1]. For example, reduction of the force of adhesion has been found between cells in tumors [5] and in target cells in animals genetically predisposed to spontaneous carcinogenesis [2]. However,(More)