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High-throughput phenotyping
Automated methods to score phenotypes in model organisms continue to develop and will permit previously inaccessible areas of biology to be probed.
Zinc-finger nucleases
Based on rapid methodological developments in 2009, last year we selected targeted proteomics analysis by mass spectrometry as a Method to Watch. Progress in 2010 continued at a quickening pace. TheExpand
Primer: genome editing with engineered nucleases
A brief description of tools for targeted cleavage and tailored modification of genomes is presented.
All that glitters but does not blink
TLDR
Silver nanoclusters are bright, stable and well suited for single-molecule applications and could be a new material for high-performance materials engineering. Expand
From structure to function
By docking potential substrates into the active site of an enzyme of known structure, researchers accurately predict the catalytic activity of the enzyme.
Genomics: The ENCODE project
The second, genome-wide phase of the Encyclopedia of DNA Elements (ENCODE) project is being reported.
Organoids.
TLDR
3D organoids that model (albeit incompletely) brain, retina, intestine and other organs of the gastrointestinal tract, kidney and liver, among several other organs are reported. Expand
Pulling on single molecules
TLDR
Single-molecule methods to apply and measure force and displacement are expanding mechanobiology, with applications in medicine, materials science, and engineering. Expand
Single-cell methods
TLDR
The ability to study single cells will permit a better understanding of cellular heterogeneity and help to understand the role of phosphorous in the response to injury. Expand
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