Natalie Yuen

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BACKGROUND AND PURPOSE KCa3.1, a calcium-activated potassium channel, regulates ion and fluid secretion in the lung and gastrointestinal tract. It is also expressed on vascular endothelium where it participates in blood pressure regulation. However, the expression and physiological role of KCa3.1 in blood-brain barrier (BBB) endothelium has not been(More)
Brain edema forms rapidly in the early hours of ischemic stroke by increased secretion of Na, Cl, and water into the brain across an intact blood-brain barrier (BBB), together with swelling of astrocytes as they take up the ions and water crossing the BBB. Our previous studies provide evidence that luminal BBB Na-K-Cl cotransport (NKCC) and Na/H exchange(More)
Background Central corneal thickness (CCT) of 74 eyes from 39 normal Hong Kong Chinese subjects with ages ranging from 39 to 86 years were studied.Aim & Purpose To compare the measurements of different devices and to compare the results of ethnic groups in other studies.Methods Non-contact measurements by Orbscan and Optical Coherence Tomography (OCT) were(More)
OBJECTIVE Cerebral edema is a life-threatening complication of diabetic ketoacidosis (DKA) in children. Recent data suggest that cerebral hypoperfusion and activation of cerebral ion transporters may be involved, but data describing cerebral metabolic alterations during DKA are lacking. RESEARCH DESIGN AND METHODS We evaluated 50 juvenile rats with DKA(More)
In this paper, we use integration method to show that there is no existence of global C 2 solution with compact support, to the pressureless Euler-Poisson equations with attractive forces in R N. And the similar result can be shown, provided that the uniformly bounded functional: Z Ω(t) Kγ(γ − 1)ρ γ−2 (∇ρ) 2 dx + Z Ω(t) Kγρ γ−1 ∆ρdx + ǫ ≥ −δα(N)M, (1) where(More)
Diabetic ketoacidosis (DKA) may cause brain injuries in children. The mechanisms responsible are difficult to elucidate because DKA involves multiple metabolic derangements. We aimed to determine the independent effects of hyperglycemia and ketosis on cerebral metabolism, blood flow, and water distribution. We used magnetic resonance spectroscopy to measure(More)
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissions in this version of the manuscript or any version derived from it by third parties. The definitive publisher-authenticated version will be available in a future(More)
OBJECTIVE Cerebral edema (CE) is a potentially life-threatening complication of diabetic ketoacidosis (DKA) in children. Osmotic fluctuations during DKA treatment have been considered responsible, but recent data instead suggest that cerebral hypoperfusion may be involved and that activation of cerebral ion transporters may occur. Diminished cerebral blood(More)
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