Folic acid enhances endothelial function and improves outcome in primary prevention of cardiovascular disease. The exact intracellular signalling mechanisms involved remain elusive and were therefore the subject of this study. Particular focus was placed on folic acid-induced changes in posttranslational modifications of endothelial nitric oxide synthase… (More)
Time series models can play an important role in disease prediction. Incidence data can be used to predict the future occurrence of disease events. Developments in modeling approaches provide an opportunity to compare different time series models for predictive power. We applied ARIMA and Random Forest time series models to incidence data of outbreaks of… (More)
OBJECTIVES To determine the incidence and risk factors of mortality for all HIV-infected patients receiving antiretroviral treatment at public and private healthcare facilities in the Botswana National HIV/AIDS Treatment Programme. DESIGN We studied routinely collected data from 226 030 patients enrolled in the Botswana National HIV/AIDS Treatment… (More)
OBJECTIVE To measure the association between the number of doctors, nurses and hospital beds per 10,000 people and individual HIV-infected patient outcomes in Botswana. DESIGN Analysis of routinely collected longitudinal data from 97,627 patients who received ART through the Botswana National HIV/AIDS Treatment Program across all 24 health districts from… (More)
evidence for the ancient origin of mixotrophy in dinoflagellates. In revision. Endosymbiotic gene transfer and photoacclimation of Paulinella chromatophora, an amoeba with nascent photosynthetic organelles originated from the second primary endosymbiosis. transfers from diverse bacteria drove organelle evolution in Paulinella chromatophora.