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BACKGROUND It is not understood why only a subset of individuals infected with Trypanosoma cruzi develop chronic Chagas cardiomyopathy (CCC). Patients with CCC display high levels of circulating proinflammatory cytokines. Heart-infiltrating lymphocytes from patients with CCC also express proinflammatory cytokines (tumor necrosis factor- alpha and(More)
In cancer, pathological tissue often exhibits abnormal perfusion and vascular permeability. These can be estimated by monitoring the abundance of an injected contrast medium over time, using Dynamic Contrast-Enhanced (DCE) MR Imaging. The resulting spatially resolved time curves are usually interpreted in terms of a pharmacokinetic model which is fitted by(More)
BACKGROUND By 2050, nearly 70% of the global population is projected to live in urban areas. Because the environments we inhabit affect our health, urban and transport designs that promote healthy living are needed. OBJECTIVE We estimated the number of premature deaths preventable under compliance with international exposure recommendations for physical(More)
BACKGROUND Physical inactivity is one of the leading risk factors for non-communicable diseases, yet many are not sufficiently active. The Physical Activity through Sustainable Transport Approaches (PASTA) study aims to better understand active mobility (walking and cycling for transport solely or in combination with public transport) as an innovative(More)
from ZLB Bioplasma AG in Bern. I would like to thank the following persons for their precious help and without whom this work would probably not have been possible: Professor Florian Maria Wurm for accepting me as a PhD student in his group, for letting me follow really interesting seminars abroad during these three years, for constructive discussions about(More)
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