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BsrG/SR4 from Bacillus subtilis--the first temperature-dependent type I toxin-antitoxin system.

• Natalie Jahn, Heike Preis, Christoph Wiedemann, S Annette Brantl
• Molecular microbiology
• 2012

Here, we describe bsrG/SR4, a novel type I toxin-antitoxin system from the SPβ prophage region of the Bacillus subtilis chromosome. The 294-nucleotide bsrG RNA encodes a 38-amino-acid toxin, whereas… (More)

One antitoxin—two functions: SR4 controls toxin mRNA decay and translation

• Natalie Jahn, S Annette Brantl
• Nucleic acids research
• 2013

Type I toxin-antitoxin systems encoded on bacterial chromosomes became the focus of research during the past years. However, little is known in terms of structural requirements, kinetics of… (More)

Against the mainstream: the membrane-associated type I toxin BsrG from Bacillus subtilis interferes with cell envelope biosynthesis without increasing membrane permeability.

• Natalie Jahn, S Annette Brantl, Henrik Strahl
• Molecular microbiology
• 2015

Toxin-antitoxin loci, which encode a toxic protein alongside with either RNA or a protein able to counteract the toxicity, are widespread among archaea and bacteria. These loci are implicated in… (More)

A multistress responsive type I toxin-antitoxin system: bsrE/SR5 from the B. subtilis chromosome.

• Peter Müller, Natalie Jahn, +4 authors S Annette Brantl
• RNA biology
• 2016

bsrE/SR5 is a type I TA system from prophage-like element P6 of the B. subtilis chromosome. The 256 nt bsrE RNA encodes a 30 aa toxin. The antitoxin SR5 is a 163 nt antisense RNA. Both genes overlap… (More)

In Vitro Characterization of the Type I Toxin-Antitoxin System bsrE/SR5 from Bacillus subtilis.

• Christin Meißner, Natalie Jahn, S Annette Brantl
• The Journal of biological chemistry
• 2016

BsrE/SR5 is a new type I toxin/antitoxin system located on the prophage-like region P6 of the Bacillus subtilis chromosome. The bsrE gene encoding a 30-amino acid hydrophobic toxin and the antitoxin… (More)

Heat-shock-induced refolding entails rapid degradation of bsrG toxin mRNA by RNases Y and J1.

• Natalie Jahn, S Annette Brantl
• Microbiology
• 2016

Gene regulation accomplished by alternative folding of an mRNA is a widely used mechanism. Classical examples are the various transcriptional attenuation mechanisms that employ, for example, leader… (More)

Type I toxin-antitoxin systems in Bacillus subtilis.

• Sylvain Durand, Natalie Jahn, Ciarán Condon, S Annette Brantl
• RNA biology
• 2012

Type I toxin-antitoxin (TA) systems are widespread in bacteria and consist of a toxin-encoding mRNA and a partially overlapping antisense RNA that blocks expression of the toxin, either at the level… (More)

sRNAs in bacterial type I and type III toxin-antitoxin systems.

• S Annette Brantl, Natalie Jahn
• FEMS microbiology reviews
• 2015

Toxin-antitoxin (TA) loci consist of two genes: a stable toxin whose overexpression kills the cell or causes growth stasis and an unstable antitoxin that neutralizes the toxin action. Currently, five… (More)

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