Natalie J. Wood

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the potential of t-cell based therapies for severe ulcerative colitis has been called into question by the findings of an international, multicenter study. two open-label trials had indicated that visilizumab—a monoclonal antibody to the t-cell receptor CD3—was efficacious for intravenous corticosteroid-refractory ulcerative colitis. william sandborn and(More)
Targeting the standard isoform of cellsurface receptor CD44 (CD44s) may have potential as a strategy for blocking the formation and post-radiotherapy recurrence of pancreatic tumours. CD44 is a receptor for hyaluronic acid (HA) and has a role in cellular processes, such as cell survival, differentiation, proliferation, adhesion, migration and(More)
The findings of a study by Richard Flavell and colleagues provide evidence of a link between inflammasomes, the gut microbiota and NAFLD (the hepatic manifestation of metabolic syndrome). Inflammasomes—proinflammatory multiprotein complexes consisting of a Nod-like receptor (NLR) protein or a PYHIN protein—sense pathogenassociated molecular patterns (PAMPs)(More)
Chlorhexidine (CHX) is an antimicrobial agent that is efficacious against gram-negative and -positive bacteria and yeasts. Its mechanism of action is based on cell membrane disruption and, as such, it does not promote the development of bacterial resistance, which is associated with the widespread use of antibiotics. In this manuscript, we report the(More)
Ethylene vinyl acetate (EVA) is in widespread use as a polymeric biomaterial with diverse applications such as intravitreal devices, catheters, artificial organs, and mouthguards. Many biomaterials are inherently prone to bacterial colonization, as the human body is host to a vast array of microbes. This can lead to infection at the biomaterial's site of(More)
the findings of a pilot study offer hope to patients with primary biliary cirrhosis (PBC) who have an incomplete response to ursodeoxycholic acid (uDCa)—the only FDa-approved treatment for the chronic cholestatic liver disease. “approximately 40% of patients with PBC do not respond completely to uDCa and may progress toward biliary cirrhosis and liver(More)
A team at Washington University School of Medicine has shown that individualized, human gut microbiota collections can be grown and manipulated in the laboratory. “This research helps set up a discovery pipeline in which we can deliberately manipulate collections of human intestinal microbes from people of different ages and cultures who are either healthy(More)
the stereotypical image of a person with nonalcoholic fatty liver (naFl) may need to re-evaluated, at least in the developing world, according to the findings of a new study by abhijit Chowdury and colleagues. the prevalence of obesity and diabetes is rising in the developing world as a result of economic prosperity and the westernization of diet and(More)
The findings of a study by general practitioners and infectious disease specialists in Norway have shown that the clinical consequences of infection with Giardia lamblia are more serious than previously thought. “There have been other outbreaks of giardiasis in Europe and North America,” explains Knut-Arne Wensaas of the Research Unit for General Practice,(More)
Thomas Baumert and colleagues used a functional high-throughput RNA interference screen to identify host factors necessary for HCV entry, because HCV entry is required for viral infection to be initiated, disseminated and maintained. They chose to focus their efforts on cellular kinases because their importance in key cellular processes has been established(More)