Natalie A. Cookson

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A major challenge for systems biology is to deduce the molecular interactions that underlie correlations observed between concentrations of different intracellular molecules. Although direct explanations such as coupled transcription or direct protein-protein interactions are often considered, potential indirect sources of coupling have received much less(More)
High-throughput technologies have led to the generation of complex wiring diagrams as a post-sequencing paradigm for depicting the interactions between vast and diverse cellular species. While these diagrams are useful for analyzing biological systems on a large scale, a detailed understanding of the molecular mechanisms that underlie the observed network(More)
The crucial role of time-keeping has required organisms to develop sophisticated regulatory networks to ensure the reliable propagation of periodic behavior. These biological clocks have long been a focus of research; however, a clear understanding of how they maintain oscillations in the face of unpredictable environments and the inherent noise of(More)
Computational modeling of biological systems has become an effective tool for analyzing cellular behavior and for elucidating key properties of the intricate networks that underlie experimental observations. While most modeling techniques rely heavily on the concentrations of intracellular molecules, little attention has been paid to tracking and simulating(More)
Throughout this supplement, N and Q are assumed to have their steady-state distributions (with either K = 0 or K > 0). In the first section, we extend the results on the moments of N given for L = 1 in the main text to the case L > 1, from which expressions for the moments and correlations for Q follow immediately. We treat the case K = 0 first and then the(More)
The SBML file of the model used for this study has been archived at the BioModels Database (MODEL1111150000). Flow cytometry data was taken with a Becton-Dickinson LSR II Cell Analyzer, fitted with 405nm and 488nm lasers. Because a wide range of fluorescence intensities arose as inducer levels were scanned, the sensitivity (set by voltage) of(More)
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