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Inappropriate regulation of the PI3-kinase/PTEN/Akt kinase-signalling cassette, a key downstream target of insulin/insulin-like growth factor signalling (IIS), is associated with several major human diseases such as diabetes, obesity and cancer. In Drosophila, studies have recently revealed that different subcellular pools of activated, phosphorylated Akt(More)
Mortalin is an essential component of the molecular machinery that imports nuclear-encoded proteins into mitochondria, assists in their folding, and protects against damage upon accumulation of dysfunctional, unfolded proteins in aging mitochondria. Mortalin dysfunction associated with Parkinson's disease (PD) increases the vulnerability of cultured cells(More)
Reversible phosphorylation of myosin regulatory light chain (MRLC) is a key regulatory mechanism controlling myosin activity and thus regulating the actin/myosin cytoskeleton. We show that Drosophila PP1beta, a specific isoform of serine/threonine protein phosphatase 1 (PP1), regulates nonmuscle myosin and that this is the essential role of PP1beta. Loss of(More)
The insulin/insulin-like growth factor signalling (IIS) cascade performs a broad range of evolutionarily conserved functions, including the regulation of growth, developmental timing and lifespan, and the control of sugar, protein and lipid metabolism. Recently, these functions have been genetically dissected in the fruit fly Drosophila melanogaster,(More)
Kolmogorov's very ÿrst paper on algorithmic information theory (Kolmogorov, Problemy peredachi informatsii 1(1) (1965) 3) was entitled " Three approaches to the deÿnition of the quantity of information ". These three approaches were called combinatorial, probabilistic and algorithmic. Trying to establish formal connections between combinatorial and(More)
The PI3K (phosphoinositide 3-kinase)/Akt (also called protein kinase B) signalling cassette plays a central role in the response to growth factors, particularly insulin-like molecules, and its misregulation is a characteristic feature of diabetes and many forms of human cancer. Recent molecular genetic studies initiated in the fruitfly, Drosophila(More)
We have identified two proteins that bind with high specificity to type 1 serine/threonine protein phosphatase (PP1) and have exploited their inhibitory properties to develop an efficient and flexible strategy for conditional inactivation of PP1 in vivo. We show that modest overexpression of Drosophila homologs of I-2 and NIPP1 (I-2Dm and NIPP1Dm) reduces(More)
The thioamides of 2-benzimidazolecarboxylic acids (III, IV) presented special interest for testing for tuberculostatic activity, since some thioamides are active antituberculosis preparations (ethionamide, protionamide) [1]. Compounds III and IV were obtained from the action of hydrogen sulfide on I and IIpyridine solution in the presence of triethylamine.(More)
Many ni t rofuryl idene der iva t ives display an t imicrobia l action [1-3]. It was of in teres t to us to synthes ize a number of 2 (5 -n i t ro -2fu ry l )v iny l der iva t ives of pyr idaz ine and check their ant i tuberculos is activity. The choice of he te rocyc le was brought about by the p r e sence of physiological activity, including an t i(More)
described [i] 5-(p-alkoxyphenyl)-5-methylhydantoins, for which anticorazole properties are also characteristic. In addition to this, lla, b, with SI = 8.3 and 8.6 and TI = i0 and 10.5, respectively, are appreciably inferior to the most active compound IV, the'Sl and TI of which are 14.3 and 14.3, respectively (see Table 4). Morpholino and dimorpholino(More)