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  • Zhi Xu, Rashna D Balsara, Natalia V Gorlatova, Daniel A Lawrence, Francis J Castellino, Victoria A. Ploplis
  • Medicine, Biology
  • Journal of Biological Chemistry
  • 2004 (First Publication: 23 April 2004)
  • Plasminogen activator inhibitor-1 is the main physiological regulator of tissue-type plasminogen activator in normal plasma. In addition to its critical function in fibrinolysis, plasminogenExpand
  • Shih-hon Li, Natalia V Gorlatova, Daniel A Lawrence, Bradford S. Schwartz
  • Chemistry, Medicine
  • Journal of Biological Chemistry
  • 2008 (First Publication: 27 June 2008)
  • Plasminogen activator inhibitor type 1 (PAI-1) is a serine protease inhibitor (serpin) in which the reactive center loop (RCL) spontaneously inserts into a central β-sheet, β-sheet A, resulting inExpand
  • Natalia V Gorlatova, Hassan Elokdah, Kristi Yi Fan, David L. Crandall, Daniel A Lawrence
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 2003 (First Publication: 2 May 2003)
  • The mechanism for the conversion of plasminogen activator inhibitor-1 (PAI-1) from the active to the latent conformation is not well understood. Recently, a monoclonal antibody, 33B8, was describedExpand
  • Kinlin L. Chao, Natalia V Gorlatova, Edward Eisenstein, Osnat Herzberg
  • Medicine, Biology
  • The Journal of Biological Chemistry
  • 2014 (First Publication: 5 September 2014)
  • Background: RON and MET receptors bind their ligands MSP and HGF selectively and activate different signaling pathways. Results: Crystallographic and analytical ultracentrifugation studies provideExpand
  • David L. Crandall, Hassan Elokdah, L Di, James K. Hennan, Natalia V Gorlatova, Daniel A Lawrence
  • Medicine
  • Journal of thrombosis and haemostasis : JTH
  • 2004 (First Publication: 1 August 2004)
  • Plasminogen activator inhibitor-1 (PAI-1) is the major physiological inhibitor of both tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA). Elevated levels of PAI-1Expand