Natalia Szostak

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Intercellular communication mediated by extracellular vesicles has proved to play an important role in normal and pathological scenarios. However not too much information about the sorting mechanisms involved in loading the vesicles is available. Recently, our group has characterized the mRNA content of vesicles released by hepatic cellular systems, showing(More)
The function of RNA is strongly dependent on its structure, so an appropriate recognition of this structure, on every level of organization, is of great importance. One particular concern is the assessment of base-base interactions, described as the secondary structure, the knowledge of which greatly facilitates an interpretation of RNA function and allows(More)
The structures of biological macromolecules provide a framework for studying their biological functions. Three-dimensional structures of proteins, nucleic acids, or their complexes, are difficult to visualize in detail on flat surfaces, and algorithms for their spatial superposition and comparison are computationally costly. Molecular structures, however,(More)
Despite years of study, it is still not clear how life emerged from inanimate matter and evolved into the complex forms that we observe today. One of the most recognized hypotheses for the origins of life, the RNA World hypothesis, assumes that life was sparked by prebiotic replicating RNA chains. In this paper, we address the problems caused by the(More)
A hypercycle is an abstract model of organization of self-replicating molecules connected in a cyclic, autocatalytic manner. It was introduced in an ordinary differential equation (ODE) form by the Nobel Prize winner Manfred Eigen in 1971 [1] and subsequently further extended in collaboration with Peter Schuster [2,3]. It was proposed as a solution to the(More)
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