Natalia Pérez-Sánchez

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Nonsteroidal anti-inflammatory drugs (NSAIDs) are used throughout the world to treat pain and inflammation; however, they can trigger several types of drug hypersensitivity reactions (DHRs) in all age groups. Although most such reactions occur through activation of the leukotriene pathway without specific immunological recognition (cross-intolerance), a(More)
BACKGROUND Pyrazolones are the most common causes of selective nonsteroidal anti-inflammatory drug (NSAID) hypersensitivity. We studied a large group of patients with immediate and delayed selective responses to metamizole. METHODS Patients with suspicion of hypersensitivity to metamizole were evaluated. We verified acetylsalicylic acid tolerance and(More)
Individual genetic background together with environmental effects are thought to be behind many human complex diseases. A number of genetic variants, mainly single nucleotide polymorphisms (SNPs), have been shown to be associated with various pathological and inflammatory conditions, representing potential therapeutic targets. Prostaglandins (PTGs) and(More)
OBJECTIVE Cross-intolerance to NSAIDs is a class of drug hypersensitivity reaction, of which NSAIDs-induced urticaria and/or angioedema (NIUA) are the most frequent clinical entities. They are considered to involve dysregulation of the arachidonic acid pathway; however, this mechanism has not been confirmed for NIUA. In this work, we assessed copy number(More)
Dear Editor in Chief: We thank Van Gasse et al. for their correspondence and for raising the question of non-IgE mechanisms of mast cell activation in hypersensitivity reactions to quinolones [1]. This interesting paper unfortunately could not be included in our review due to its recent publication. Anaphylactic reactions induced by drugs through a(More)
PURPOSE OF REVIEW Quinolones are a group of synthetic antibiotics widely use as first-line treatment for many infections. There has been an increase in the incidence of hypersensitivity reactions to quinolones in recent years, likely due to increased prescription. The purpose of this review is to summarize the clinical pictures, the methods used for(More)
BACKGROUND AND OBJECTIVES Individuals who develop drug hypersensitivity reactions (DHRs) to chemically unrelated nonsteroidal anti-inflammatory drugs (NSAIDs) are considered cross-hypersensitive. The hallmark for this classification is that the patient presents a reaction after intake of or challenge with acetylsalicylic acid (ASA). Whether patients react(More)
AFFILIATION: a Allergy Service, Infanta Leonor Hospital, Madrid, Spain; b Allergy Unit, Malaga Regional University Hospital-IBIMA, UMA, Malaga, Spain; c Research Laboratory, Malaga Regional University Hospital-IBIMA, UMA, Malaga, Spain; d Chemical Technology Institute, UPV-CSIC, Polytechnic University of Valencia, Valencia, Spain; e Allergy Unit, Pneumology(More)