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OBJECTIVES To examine the efficacy of an integrative cognitive training program (REHACOP) to improve cognition, clinical symptoms, and functional disability of patients with Parkinson disease (PD). METHODS Forty-two patients diagnosed with PD in Hoehn & Yahr stages 1 to 3 were randomly assigned to either the cognitive training group (REHACOP) or the(More)
Results of this PET-O15 water activation study confirm the implication of supplementary motor areas during time estimation tasks. They also show that the cortical-subcortical network associated with temporal processing is impaired in schizophrenia. Following recent proposals of time dynamic networks, this impairment may consist in a dysfunctional imbalance(More)
We examined changes in relative cerebral flood flow (relCBF) using PET during a sustained attention paradigm which included auditory stimulation and different tasks of mental counting. Ten normal volunteers underwent PET (15O water) during a baseline state and under experimental conditions which included listening to clicks, serial counting with auditory(More)
The self-medication hypothesis attempts to explain the extraordinary high levels of cigarette smoking in schizophrenia; patients may smoke in an attempt to reduce their cognitive deficits, symptoms, or the side effects of antipsychotics. In a previous report, we detected beneficial performance in attention and working memory in patients with first-episode(More)
Deficits in sustained attention have been frequently described in schizophrenia. The neuroanatomical basis reported previously have included altered levels of activation in cingulate and prefrontal cortex, but the contribution of further regions remains unclear. We explored the full neuroanatomy underlying the sustained attentional deficits observed in(More)
OBJECTIVE We sought to determine whether a single hypothesized latent factor structure would characterize cognitive functioning in three distinct groups. METHODS We assessed 576 adults (340 community controls, 126 adults with bipolar disorder, and 110 adults with schizophrenia) using 15 measures derived from nine cognitive tests. Confirmatory factor(More)
OBJECTIVE Decreased processing speed (PS) is a key feature of schizophrenia with respect to cognition, functional outcome and clinical symptoms. Our objective was to test whether PS slowing mediates other neuropsychological deficits among patients with chronic schizophrenia. METHOD One hundred patients with schizophrenia and 53 healthy adults completed a(More)
  • Pedro Sánchez, Javier Peña, +4 authors Miguel Gutiérrez
  • 2014
(DAS-WHO). In addition to receiving standard treatment, patients were randomly assigned either to receive neuropsy-chological rehabilitation (REHACOP) or to a control group. REHACOP is an integrative program that taps all basic cog-nitive functions. The program included experts' latest suggestions about positive feedback and activities of daily living in(More)
The aims of this study were to analyze the presence of gender differences in the phenotypic expression of schizophrenia at the onset of illness and to explore whether these differences determine clinical and functional outcome 2 years after the initiation of treatment. Data from 231 first-episode-psychosis non-substance-dependent patients (156 men and 75(More)
Verbal fluency and verbal memory have been reported to be diminished in patients with schizophrenia. These deficits could partially predict functional disability in this pathology. However, processing speed often mediates the relationship among cognitive processes in the disorder. Our goal was to analyse the influence of processing speed as mediator of the(More)