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Oncogenic transcription factors such as RUNX1/ETO, which is generated by the chromosomal translocation t(8;21), subvert normal blood cell development by impairing differentiation and driving malignant self-renewal. Here, we use digital footprinting and chromatin immunoprecipitation sequencing (ChIP-seq) to identify the core RUNX1/ETO-responsive(More)
The lentiviral construct pHR-cPPT-SIEW-RUNX1/ETO (p-SIEW-RR) was generated by inserting the RUNX1/ETO coding region into the BamHI site in the pHR-cPPT-SIEW lentiviral transfer vector (kindly provided by Michela Scherr, Hannover) thus linking RUNX1/ETO with enhanced green fluorescent protein (EGFP) expression via an internal ribosomal entry site(More)
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