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Journals and Conferences
In microbial mat communities of Yellowstone hot springs, ribosomal RNA (rRNA) sequence diversity patterns indicate the presence of closely related bacterial populations along environmental gradients of temperature and light. To identify the functional bases for adaptation, we sequenced the genomes of two cyanobacterial (Synechococcus OS-A and OS-B')… (More)
The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulation in various tissues. The primary goals of this project were to identify MATE1 inhibitors with clinical… (More)
It is well known that the s-wave Jost function for a potential, λV , is an entire function of λ with an infinite number of zeros extending to infinity. For a repulsive V, and at zero energy, these zeros of the ”coupling constant”, λ, will all be real and negative, λn(0) < 0. By rescaling λ, such that λn < −1/4, and changing variables to s, with λ = s(s −… (More)
Solute Carrier (SLC) transporters are membrane proteins that transport solutes, such as ions, metabolites, peptides, and drugs, across biological membranes, using diverse energy coupling mechanisms. In human, there are 386 SLC transporters, many of which contribute to the absorption, distribution, metabolism, and excretion of drugs and/or can be targeted… (More)
The solute carrier 6 (SLC6) is a family of ion-dependent transporters that mediate uptake into the cell of osmolytes such as neurotransmitters and amino acids. Four SLC6 members transport GABA, a key neurotransmitter that triggers inhibitory signaling pathways via various receptors (e.g., GABA(A)). The GABA transporters (GATs) regulate the concentration of… (More)
Next-generation sequencing technologies are fueling a wave of new diagnostic tests. Progress on a key set of nine research challenge areas will help generate the knowledge required to advance effectively these diagnostics to the clinic.
A plethora of innovative new medical products along with the need to apply modern technologies to medical-product evaluation has spurred seminal opportunities in regulatory sciences. Here, we provide eight examples of regulatory science research for diverse products. Opportunities abound, particularly in data science and precision health.
Although rigorous clinical studies are required before a drug is placed on the market, it is impossible to predict all side effects for the approved medication. The United States Food and Drug Administration actively monitors approved drugs to identify adverse events. The FDA Adverse Event Reporting System (FAERS) contains a database of adverse drug events… (More)
Conditions are established for the existence of a scattering length and an effective range in the low-energy expansion of the S-wave phase-shift of a central potential in two and three dimensions. The behavior of the phase-shift as a function of the momentum is also derived for longer-range power-law potentials which do not fulfill these conditions. ar X iv… (More)