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In microbial mat communities of Yellowstone hot springs, ribosomal RNA (rRNA) sequence diversity patterns indicate the presence of closely related bacterial populations along environmental gradients of temperature and light. To identify the functional bases for adaptation, we sequenced the genomes of two cyanobacterial (Synechococcus OS-A and OS-B')(More)
The human multidrug and toxin extrusion (MATE) transporter 1 contributes to the tissue distribution and excretion of many drugs. Inhibition of MATE1 may result in potential drug-drug interactions (DDIs) and alterations in drug exposure and accumulation in various tissues. The primary goals of this project were to identify MATE1 inhibitors with clinical(More)
Solute Carrier (SLC) transporters are membrane proteins that transport solutes, such as ions, metabolites, peptides, and drugs, across biological membranes, using diverse energy coupling mechanisms. In human, there are 386 SLC transporters, many of which contribute to the absorption, distribution, metabolism, and excretion of drugs and/or can be targeted(More)
The solute carrier 6 (SLC6) is a family of ion-dependent transporters that mediate uptake into the cell of osmolytes such as neurotransmitters and amino acids. Four SLC6 members transport GABA, a key neurotransmitter that triggers inhibitory signaling pathways via various receptors (e.g., GABA(A)). The GABA transporters (GATs) regulate the concentration of(More)
A plethora of innovative new medical products along with the need to apply modern technologies to medical-product evaluation has spurred seminal opportunities in regulatory sciences. Here, we provide eight examples of regulatory science research for diverse products. Opportunities abound, particularly in data science and precision health.
It is well known that the s-wave Jost function for a potential, λV , is an entire function of λ with an infinite number of zeros extending to infinity. For a repulsive V, and at zero energy, these zeros of the " coupling constant " , λ, will all be real and negative, λ n (0) < 0. By rescaling λ, such that λ n < −1/4, and changing variables to s, with λ =(More)
Although rigorous clinical studies are required before a drug is placed on the market, it is impossible to predict all side effects for the approved medication. The United States Food and Drug Administration actively monitors approved drugs to identify adverse events. The FDA Adverse Event Reporting System (FAERS) contains a database of adverse drug events(More)
For a very large class of potentials, V (x), x ∈ R 2 , we prove the uni-versality of the low energy scattering amplitude, f (k ′ , k). The result is f = π 2 {1/log k) + O(1/(log k) 2). The only exceptions occur if V happens to have a zero energy bound state. Our new result includes as a special subclass the case of rotationally symmetric potentials, V (|(More)