Natalia Karmen

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Clinical experience of Perftoran (commercial drug of low concentrated perfluorocheminal emulsion) applications is presented in some statistical data and in brief analysis of clinical trials and following clinical studies described in the Russian scientific literature. Observed data allow us to suppose that Perftoran facilitates oxygen delivery together with(More)
Acute posttraumatic period of severe maxillofacial trauma in case of hyperbaric oxygenation therapy is followed by expressed activation of lipide-peroxide-oxidation (LPO) in erythrocytic membrane on the background of significant reduction of the substrate for fermentative antioxidation system (AOS). Imbalance in the system LPO:AOS is followed by expressed(More)
Acute posttraumatic period of severe craniocerebral trauma is associated with sharp activation of LPO processes and rapid exhaustion of antioxidant enzymes and especially low-molecular-weight antioxidant system in the liquor. This leads to the development of severe oxidative stress and failure of adaptation processes during the early posttraumatic period.
For acute posttraumatic period of heavy combined cranium-facial trauma (CFT) considerable activation of peroxide lipids oxidation in the liquor is typical beginning from the 1st day of posttraumatic period on the background of speedy and drastic depletion of fermentative and low-molecular antioxidant liquor system (in spite of introduction of antioxidants(More)
We studied the effect of single intravenous injection of perftoran on the intensity of the initial stages of lipid peroxidation and structural and functional characteristics of erythrocyte membranes (cell model). Perftoran slightly activated the initial stages of lipid peroxidation and optimized structural and functional characteristics of erythrocyte(More)
Central and peripheral bloodflow before and after intramuscular and intravenous injections of 0.9% NaCl (control groups, n=20) and perfluothane (n=20) in a dose of 5 ml/kg was studied in 40 Wistar rats. Dopplerographic study of the bloodflow was carried out on a diagnostic device Biomedical AU-5 (Italy). The study showed that intramuscular injections of(More)
Acute posttraumatic stage of severe craniocerebral trauma was characterized by considerable activation of lipid peroxidation and exhaustion of the antioxidant enzyme system. Oxidative modification of membranes was accompanied by structural and functional changes. The antihypoxic effect of clonidine was realized directly in the lipid phase of membranes. This(More)
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