Natalia Gonzalo

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BACKGROUND Patients with severe idiopathic Parkinson's disease experience motor fluctuations, which are often difficult to control. Accurate mapping of such motor fluctuations could help improve patients' treatment. OBJECTIVE The objective of the study was to focus on developing and validating an automatic detector of motor fluctuations. The device is(More)
BACKGROUND We conducted a phase I study in patients with advanced solid tumours to identify the recommended dose, assess pharmacokinetics (PK), pharmacodynamic activity and preclinical antitumour efficacy of the combination of sirolimus and gemcitabine. METHODS Nineteen patients were treated with sirolimus 2 or 5 mg daily and gemcitabine 800 or 1000 mg(More)
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