Natalia D. Nikolova

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Progress curve analysis is a convenient tool for the characterization of enzyme action: a single reaction mixture provides multiple experimental measured points for continuously varying amounts of substrates and products with exactly the same enzyme and modulator concentrations. The determination of kinetic parameters from the progress curves, however,(More)
The form of the utility function over multi-dimensional consequences depends on the point estimates of the scaling constants. Fuzzy rational decisionmakers elicit those in the form of uncertainty intervals. The paper proposes an analytical justification and a numerical realization of the uniform method that finds point estimates of interval scaling(More)
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A common problem in statistics is finding a distribution that fits to a certain dataset. Many theoretical distributions have been developed to give a good description of the empirical observations, and consequently, theory offers a variety of algorithms to test the quality of the resulting fits. It is reasonable to expect that each set of measurements(More)
INTRODUCTION Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS Thrombi removed by thromboaspiration following acute(More)