Natalia D. Nikolova

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Progress curve analysis is a convenient tool for the characterization of enzyme action: a single reaction mixture provides multiple experimental measured points for continuously varying amounts of substrates and products with exactly the same enzyme and modulator concentrations. The determination of kinetic parameters from the progress curves, however,(More)
A common problem in statistics is finding a distribution that fits to a certain dataset. Many theoretical distributions have been developed to give a good description of the empirical observations, and consequently, theory offers a variety of algorithms to test the quality of the resulting fits. It is reasonable to expect that each set of measurements(More)
INTRODUCTION Fibrin structure and cellular composition of thrombi profoundly affect the clinical outcomes in ischemic coronary and peripheral artery disease. Our study addressed the interrelations of structural features of thrombi and routinely measured laboratory parameters. MATERIALS AND METHODS Thrombi removed by thromboaspiration following acute(More)
Elicitation of utilities is among the most time consuming tasks in decision analysis. We search for ways to shorten this phase without compromising the quality of results. We use the results from an empirical experiment with 104 participants. They elicited 9 inner nodes from their one-dimensional utility function over monetary gains and losses using three(More)
The paper deals with ranking risky alternatives whose consequences form a one-dimensional piece-wise continuous set where the uncertainty is described by a classical one-dimensional CDF, with possible discontinuities. The alternatives can be modeled as one-dimensional classical risky generalized lotteries of either type I or III. The expected utility of(More)
Generalized lotteries of III type apply to cases, where both the number of alternatives and the number of consequences are countless. Since real decision makers elicit probabilities in an interval form, they disobey axioms of rationality and are called fuzzy rational decision makers. Generalized lotteries of III type, where the probability is partially(More)