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The K-Cl cotransporter KCC2 plays an essential role in neuronal chloride homeostasis, and thereby influences the efficacy and polarity of GABA signaling. Although KCC2 is expressed throughout the somatodendritic membrane, it is remarkably enriched in dendritic spines, which host most glutamatergic synapses in cortical neurons. KCC2 has been shown to… (More)
84 patients with duodenal ulcer and positive by Helicobacter pylori (HP) were divided into two groups. Group 1 consisted of 42 patients who received omeprasol, metranidasol and clarithromycin. Group 2 of 42 patients received rovamycin instead of clarythromycin. The results of the study show that anti-HP regimen with rovamycin is superior to clarythromycin… (More)
AIM To study effects of long-term administration of ACE inhibitor ramipril (hartil) on renin-angiotensin-aldosteron system (RAAS), dynamics of clinical symptoms of the disease and structural-functional indices of the right and left ventricle (RV, LI) in patients with chronic obstructive pulmonary disease (COPD) with decompensated chronic cor pulmonale… (More)
The supplementation of the angiotensin-converting enzyme inhibitor ramipril to combined therapy in patients with chronic obstructive bronchitis complicated by chronic cor pulmonale resulted in positive central, pulmonary, and peripheral hemodynamic changes, improved peripheral tissue oxygenation, by exerting beneficial effects on the course of the disease.
Atherosclerosis is a leading cause of morbidity and mortality in Western society. Despite improved insight into disease pathogenesis and therapeutic options, additional treatment strategies are required. Emerging evidence highlights the relevance of endothelial cell (EC) metabolism for angiogenesis, and indicates that EC metabolism is perturbed when ECs… (More)
AIM To study clinical efficacy and antihelicobacter activity of combined treatment of duodenal ulcer (DU) with famotidin (qamatel), metronidasol (trichopol) and jozamycin (walpraphen). MATERIAL AND METHODS A total of 96 patients with uncomplicated DU have been treated (mean age 42.5 +/- 1.5 years). The examination included standard tests, endoscopy,… (More)
Course and systematic long-term noliprel therapy of chronic obstructive lung disease (COLD) complicated by chronic pulmonary heart permitted to arrest or significantly slow down further progress of heart remodeling, impairment of systolic and diastolic function of right and left chamber and to decrease pressure in the pulmonary artery. These changes… (More)