• Publications
  • Influence
Mitochondrial Substrate Level Phosphorylation Is Essential for Growth of Procyclic Trypanosoma brucei *
TLDR
Results show that oxygen-independent substrate level phosphorylation either linked to the citric acid cycle or tied into acetate production is essential for growth of procyclic T. brucei, a situation that may reflect an adaptation to the partially hypoxic conditions in the insect host. Expand
Eukaryotic-type elongator tRNAMet of Trypanosoma brucei becomes formylated after import into mitochondria
TLDR
It is shown that unexpectedly a fraction of elongator tRNAMet becomes formylated after import into mitochondria, and RNA interference assays identify the gene encoding the trypanosomal formylase activity. Expand
Temporal dissection of Bax‐induced events leading to fission of the single mitochondrion in Trypanosoma brucei
The protozoan Trypanosoma brucei has a single mitochondrion and lacks an apoptotic machinery. Here we show that expression of the proapoptotic protein Bax in T. brucei causes the release ofExpand