Nasrulla D. Abdullaev

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Early pharmacological studies of Aconitum and Delphinium sp. alkaloids suggested that these neurotoxins act at site 2 of voltage-gated Na(+) channel and allosterically modulate its function. Understanding structural requirements for these compounds to exhibit binding activity at voltage-gated Na(+) channel has been important in various fields. This paper(More)
It was established that steroidal genins and their glycosides of the spirostan series and (especially) furostan series show anticestodal activity against Hymeiolepis nana species. Search for anthelminthic agents in the indicated series of compounds is a promising direction of research.
7-O-Methylglabranin, 6-C-prenylpinocembrin, glabranin, pinocembrin, galangin, and a novel isoflavonoid, (E)-5,7,4'-trihydroxy-6-(3-hydroxymethyl-2-butenyl)isoflavone (glabrisoflavone) were isolated from the aerial parts of Glycyrrhiza glabra L. The structure of the novel isoflavonoid was elucidated on the basis of chemical transformations and spectral data.
Plants of the genus Alhagi Tourn. ex Adans. (Fabaceae) have an expansive distribution range. They grow in Africa, Southern Europe, Asia, and Central Asia. The plants prefer dry steppes and stony and clayey semi-arid and arid lands. Seven Alhagi species are described in the global flora, of which five grow in Uzbekistan, i.e., A. pseudalhagi (M. Bieb.) Desv.(More)
INTRODUCTION The genus Leonurus L. (fam: Lamiaceae) is represented in Uzbekistan by two species, L. panzerioides Popov. and L. turkestanicus V. I. Krecz. & Kuprian, which are used to treat nervous disorders and also as sedative and hypotensive agents. OBJECTIVES To establish the taxonomic status of Leonurus panzerioides and L. turkestanicus based on their(More)
Mausolea eriocarpa (Bunge) Poljakov is the only species in the monotypic genus Mausolea Bunge and belongs to the Anthemideae tribe of the family Asteraceae. The species was described by Bunge in the genus Artemisia L. as A. eriocarpa Bunge. In 1961, Poljakov separated it as a special genus based on several morphological traits [1]. Later, it was(More)
A series of phytoecodysteroids, including alpha-ecdysone, 2-deoxy-alpha-ecdysone, and 2-deoxyecdysterone isolated from Silene praemixta, integristerone A and ecdysterone isolated from Rhaponticum carthamoides and 22-acetylcyasterone and turkesterone isolated from Ajuga turkestanica, exhibit a pronounced hypoglycemic effect in experiments on intact male(More)
The new caurene-type diterpenoid diglycoside puligiendioside was isolated from Pulicaria uliginosa. Its structure was established using PMR and 13C NMR spectral data and DEPT, HSQC, HMBC, and COSY experiments. The stereochemical features and absolute configuration of asymmetric centers were determined by an X-ray crystal structure analysis. Crystals of the(More)