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Stabilization of alpha-chymotrypsin at the CH2Cl2/water interface and upon water-in-oil-in-water encapsulation in PLGA microspheres.
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Antibacterial activity of 2-alkynoic fatty acids against multidrug-resistant bacteria.
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First total synthesis and antiprotozoal activity of (Z)-17-methyl-13-octadecenoic acid, a new marine fatty acid from the sponge Polymastia penicillus.
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Novel Very Long-Chain α-Methoxylated Δ5,9 Fatty Acids from the Sponge Asteropus niger Are Effective Inhibitors of Topoisomerases IB
TLDR
1a and 1b represent a new class of FA with potential as TopIB inhibitors that preferentially inhibit hTopIB over LTopIB.
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Novel Cyclopropane Fatty Acids from the Phospholipids of the Caribbean Sponge Pseudospongosorites suberitoides
TLDR
The novel cyclopropyl fatty acids could have originated from the phospholipids of a cyanobacterium living in symbiosis with the hermit-crab sponge Pseudospongosorites suberitoides.
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Synthesis of Marine α-Methoxylated Fatty Acid Analogs that Effectively Inhibit the Topoisomerase IB from Leishmania donovani with a Mechanism Different from that of Camptothecin
TLDR
The total synthesis of (5Z,9Z)-(±)-2-methoxy-5,9-eicosadienoic acid and its acetylenic analog and it is reported that they inhibit the Leishmania donovani DNA topoisomerase IB enzyme (LdTopIB), indicating that the effectiveness of inhibition depends on the degree of unsaturation.
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Chemical conjugation of 2-hexadecynoic acid to C5-curcumin enhances its antibacterial activity against multi-drug resistant bacteria.
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First total syntheses of (Z)-15-methyl-10-hexadecenoic acid and the (Z)-13-methyl-8-tetradecenoic acid.
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First total synthesis and antileishmanial activity of (Z)-16-methyl-11-heptadecenoic acid, a new marine fatty acid from the sponge Dragmaxia undata.
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The first total synthesis of the (±)-17-methyl-trans-4,5-methyleneoctadecanoic acid and related analogs with antileishmanial activity.
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