Faculty Opinions recommendation of Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.
- P. Griffin, Naresh Kumar
- Medicine
- 16 July 2010
Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ)
- Naresh Kumar, P. Nuhant, P. Griffin
- Biology
- 14 March 2013
Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation
- T. Kamenecka, S. Busby, P. Griffin
- Biology
- 7 March 2013
One such compound is described, ML244, which has a unique mode of binding to PPARγ, has potent anti-diabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PParγ drugs.
Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.
- S. Busby, Naresh Kumar, P. Griffin
- BiologyACS Chemical Biology
- 17 June 2011
SR-0065 represents a new class of non-acid, non-retinoid RAR modulator that may be used as a point to initiate development of improved RAR-targeted drugs.
A Second Class of Nuclear Receptors for Oxysterols: Regulation of ROR α and ROR γ activity by 24 S -Hydroxycholesterol (Cerebrosterol)
- Yongjun Wang, Naresh Kumar, C. Crumbley, P. Griffin, P. Thomas, Burris
- Biology
- 2010
It is shown that another oxysterol, 24 S -hydroxycholesterol (24 S -OHC), is also a high affinity ligand for ROR α and ROR γ (K i ∼ 25 nM), showing an overlapping ligand preference with another class of oxysterols nuclear receptors, the liver X receptors.
Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)
- Naresh Kumar, L. Solt, P. Griffin
- Biology, Chemistry
- 11 March 2011
The Scripps Research Institute Molecular Screening Center (SRIMSC) implemented a Center-Based Component (CBC) that focuses on the use of a genomic screening platform to support selectivity profiling…
Predicting COVID-19 cases using SARS-CoV-2 RNA in air, surface swab and wastewater samples
- H. Solo-Gabriele, Shelja Kumar, Naresh Kumar
- BiologyScience of the Total Environment
- 1 October 2022
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