Faculty Opinions recommendation of Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.
Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Gamma (RORγ)
Potent Anti-Diabetic Actions of a Novel Non-Agonist PPARγ Ligand that Blocks Cdk5-Mediated Phosphorylation
One such compound is described, ML244, which has a unique mode of binding to PPARγ, has potent anti-diabetic activity while not causing the fluid retention and weight gain that are serious side effects of many of the PParγ drugs.
Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors.
SR-0065 represents a new class of non-acid, non-retinoid RAR modulator that may be used as a point to initiate development of improved RAR-targeted drugs.
A Second Class of Nuclear Receptors for Oxysterols: Regulation of ROR α and ROR γ activity by 24 S -Hydroxycholesterol (Cerebrosterol)
It is shown that another oxysterol, 24 S -hydroxycholesterol (24 S -OHC), is also a high affinity ligand for ROR α and ROR γ (K i ∼ 25 nM), showing an overlapping ligand preference with another class of oxysterols nuclear receptors, the liver X receptors.
Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)
The Scripps Research Institute Molecular Screening Center (SRIMSC) implemented a Center-Based Component (CBC) that focuses on the use of a genomic screening platform to support selectivity profiling…
Predicting COVID-19 cases using SARS-CoV-2 RNA in air, surface swab and wastewater samples
Figure 8, Dose response curves of ML244 ( Left panel) and SR1824 (Right panel) as compared to rosiglitazone in the competitive Lanthascreen assay (n=3)