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  • Narayanaswamy Ramesh, Inés María Antón, John H. Hartwig, Raif S Geha
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 1997 (First Publication: 23 December 1997)
  • Wiskott-Aldrich syndrome (WAS) is an X-linked immunodeficiency caused by mutations that affect the WAS protein (WASP) and characterized by cytoskeletal abnormalities in hematopoietic cells. By usingExpand
  • Narcisa Martinez-Quiles, Hsin-Yi Henry Ho, Marc W Kirschner, Narayanaswamy Ramesh, Raif S Geha
  • Medicine, Biology
  • Molecular and Cellular Biology
  • 2004 (First Publication: 15 June 2004)
  • ABSTRACT The Arp2/3 complex can be independently activated to initiate actin polymerization by the VCA domain of WASP family members and by the acidic N-terminal and F-actin-binding repeat region ofExpand
  • Inés María Antón, Wenhong Lu, Bruce J. Mayer, Narayanaswamy Ramesh, Raif S Geha
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1998 (First Publication: 14 August 1998)
  • Nck is a ubiquitous adaptor molecule composed of three Src homology 3 (SH3) domains followed by a single SH2 domain. Nck links, via its SH2 domain, tyrosine-phosphorylated receptors to effectorExpand
  • Jordan S. Orange, Narayanaswamy Ramesh, +7 authors Jack L. Strominger
  • Medicine, Biology
  • Proceedings of the National Academy of Sciences…
  • 2002 (First Publication: 12 August 2002)
  • The Wiskott–Aldrich syndrome (WAS) is a primary immunodeficiency disorder caused by a mutation in WAS protein (WASp) that results in defective actin polymerization. Although the function of manyExpand