Naoyuki Ishimaru

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PURPOSE A new animal model, the NFS/sld mutant mouse, was used for primary Sjögren's syndrome to investigate the efficacy of topical and systemic cyclosporin A (CyA) in preventing inflammation of the exocrine glands. METHODS Cyclosporin A was applied topically (0.01% and 0.1%, three times a day) or administered orally (10 mg/kg and 100 mg/kg, once a day)(More)
Brain function dynamics related to an inhibitory interference in voluntary motor abandonment was investigated with single-pulse transcranial magnetic stimulation (TMS) and electroencephalogram (EEG). As the voluntary motor movement, a point-to-point reaching movement of the right index-finger was conducted. The starting time of the movement was indicated(More)
MRL/Mp +/+ (MRL/+) mice, not bearing the lpr gene, are known to have age-related autoimmune lesions in several organs such as pancreas, salivary and lacrimal glands at 30-weeks-old or more. In this study, MRL/+ mice were ovariectomized at 4-weeks-old, and their natural histories were analysed. Ovariectomy (Ovx) of MRL/+ mice led to marked acceleration of(More)
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