Naoya Seta

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OBJECTIVES To identify genes which are more highly expressed in the peripheral blood mononuclear cells (PBMC) of patients with spondyloarthropathy (SpA), rheumatoid arthritis (RA) and psoriatic arthritis (PsA), in comparison to normal subjects. METHODS A 588-gene microarray was used as a screening tool to select a panel of such genes from PBMC of these(More)
HLA-B27 confers a very strong genetic predisposition to development of a reactive arthritis after infection by bacteria such as Salmonella typhimurium. This study examines the role of HLA-B27 in the initiation of the earliest host activities after exposure to Salmonella, namely activation of the immediate early genes in the epithelial cells. Our major(More)
OBJECTIVE Reactive arthritis (ReA) is postulated to be caused by a defective host defense against gram-negative bacteria. HLA-B27 could play a role in this process, but does not account for the many HLA-B27 negative patients. The objective of this study was to test the expression of 3 macrophage scavenger receptors (SRs) that are responsible for innate(More)
OBJECTIVES To validate the use of cDNA based microarray on synovial biopsies by analysing the experimental variability due to amplification of RNA, reproducibility of the assay, heterogeneity of the tissue, and statistical analysis. METHODS Total RNA was extracted from three spondyloarthropathy (SpA) and three osteoarthritis (OA) synovial tissue biopsy(More)
With the explosive proliferation of WLANs (wireless local area networks), their inter-working with other existing wireless mobile networks, such as 3G cellular networks, is being actively promoted by carriers to achieve ubiquitous broadband communication. Fast authentication is essential to achieve seamless handover in such an environment. Existing fast(More)
As development of highspeed network, intelligent multimedia workstation and large-scale storage device technologies, distributed multimedia information services are now making their appearance. However, despite the int,ense media attention currently being showered on multimedia, many obstacles remain to be overcome before practical, widespread applications(More)
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