Naoya Niimi

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Mouse mammary tumor virus (MMTV) has an open reading frame (Off) in its 3' long terminal repeat (LTR) encoding a superantigen (Sag) that binds major histocompatibility complex (MHC) class II molecules and stimulates T cells bearing particular TcrV~ (Acha-Orbea and MacDonald 1995). Although 3'LTROrf-encoded protein alone is able to determine the TcrV[3(More)
Similar to the superantigens encoded by endogenous mouse mammary tumor virus (MMTV) proviruses (Acha-Orbea et al. 1993), infectious MMTVs express superantigens, which are recognized by particular Tcrb-V in the context of MHC class II molecules (Marrack et al. 1991). Choi and coworkers (1991) and Acha-Orbea and co-workers (1991) have reported independently(More)
The manor lymphocy~-stmaulamag ~mtagen (MIs), whach as defined by the demoustrataon of a strong lYnmary T-cell pmhferenve response m a maxed lymphocyte culture between major hastocompafibthty complex-ldenlncal stratus (Fe.mmstem et aL 1989), ts a represemtafive of self superantagens (Sags) Whlda brad to certain Tcrb-V elements a~d delete T ceils bearing(More)
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