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UNLABELLED After traumatic brain injury (TBI), subcortical white matter damage may induce a functional disconnection leading to a dissociation of regional cerebral metabolic rate of glucose (CMRglc) between the cerebral cortex and deeper brain regions. Therefore, thalamic and brain stem CMRglc may have a closer correlation than does the cerebral cortex with(More)
The aim of this study was to determine whether the apparent loss of overall gray-white matter contrast (GM/WM) seen on FDG-PET imaging reflects the differential changes of glucose metabolic rate (CMRglc) in cortical gray mater (GM) and subcortical white mater (WM) following TBI. The clinical significance of the CMRglc GM-to-WM ratio was also evaluated.(More)
OBJECTIVE We used positron emission tomographic studies to prospectively examine the relationship between glucose and oxidative metabolism in the subcortical white matter (WM) acutely after traumatic brain injury (TBI). The objective was to determine the nature, extent, and degree of metabolic abnormalities in subcortical brain regions remote from(More)
UNLABELLED Patients with mild traumatic brain injury (TBI) often complain of cognitive fatigue during the chronic recovery phase. The Paced Auditory Serial Addition Test (PASAT) is a complex psychologic measure that may demonstrate subtle deficiencies in higher cognitive functions. The purpose of this study was to investigate the brain activation of(More)
PURPOSE Cognitive impairment is a representative neuropsychiatric presentation that accompanies Parkinson disease (PD). The purpose of this study was to localize the cerebral regions associated with cognitive impairment in patients with PD using quantitative SPECT. PATIENTS AND METHODS Thirty-two patients with PD (mean [SD] age, 75 [8] years; 25 women;(More)
To achieve both high clock rate and high IPC of microprocessors, clustered architecture has been proposed. In this architecture, instruction should be steered into " the cluster with minimum Issue Delay ". But to detect such a cluster causes too complex calculation. Therefore, prior instruction steering algorithms use some approximations. This paper(More)
To achieve both high clock rate and high IPC of microprocessors, clustered architecture has been proposed. In this architecture, small number of computation resources is clustered, and the clusters are interconnected each other. Each of them performs at high clock rate, but has only narrow throughput. Therefore, instruction workload of each cluster should(More)
Objective: Cerebral blood flow (CBF) estimation with C 15 O 2 PET usually assumes a single tissue compartment model and a fixed brain-blood partition coefficient of water. However, the partition coefficient may change in pathologic conditions. The purpose of this study was to investigate the changes of partition coefficient of water in pathological regions(More)