Naosuke Sugai

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From 92,686 sera sent from hospitals throughout Japan to the Special Reference Laboratories for CH50 assay, we were able to classify 80 patients as C9-deficient using a sensitive screening test, as well as hemolytic and immunochemical C9 assays. The incidence of C9 deficiency was determined to be 0.086%, and there were no distinct differences among the(More)
PURPOSE General anaesthetic agents and aging affect cerebrovascular CO2 reactivity (CCO2R). The purpose of this study was to investigate the effect of aging on CCO2R in patients during sevoflurane anaesthesia. METHODS Twenty-four patients were divided into two groups of 12 according to age; 20-40 yr and 50-70 yr. Anaesthesia was induced with 5
The effects of nitrous oxide alone and combination of nitrous oxide and fentanyl on spinal reflexes were studied in cats with transected spinal cord at the thoracic level. Nitrous oxide 33, 50 and 75% in oxygen depressed the amplitude of monosynaptic reflexes in a dose-dependent manner, but exerted little effect on polysynaptic reflexes. The addition of(More)
The effects of adding midazolam and bupivacaine to human cerebrospinal fluid in glass test tubes were examined by looking for changes in pH and a reduction in the transparency of the solution. Midazolam (n = 6), 0.25% bupivacaine (n = 6), 5 mg of midazolam in 6 mL of 0.25% bupivacaine (n = 6) and 5 mg of midazolam in 10 mL of saline (n = 6) were added to(More)
A computer program written mainly in a high level language (ALGOL), but with the sampling routine and certain calculations written in assembly language (SIR), has been developed to assess neuromuscular blockade in anaesthetized man by means of an Elliott 903 digital computer. The program allows the on-line real-time analysis of a range of variables(More)
The tetanic force development of the human adductor pollicis muscle was studied under light anesthesia with nitrous oxide, oxygen, and Demerol, by the use of tetanic stimulation of the ulnar nerve at frequencies ranging from 10 to 100 Hz. The time necessary for the tetanic contraction to reach a plateau was longest at frequencies between 15 and 20 Hz.(More)
Tetanic and single twitch contractions of the adductor pollicis muscle in anaesthetized man were measured continuously following the i.v. injection of tubocurarine 0.2 mg/kg. Tetanic contractions were depressed earlier by tubocurarine and to a greater extent compared with the single twitch. Recovery was also slower for the tetanic contractions. The fade of(More)