Naomi Tsuchiyama

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OBJECTIVE Inappropriate excessive secretion of glucagon, which contributes to postprandial hyperglycemia, is a novel target for the treatment of diabetes. In this study, we sought to determine the factors associated with exaggerated glucagon secretion in response to an arginine challenge in patients with type 1 and type 2 diabetes. RESEARCH DESIGN AND(More)
This study investigated whether strict control of plasma glucose levels with mealtime dosing of a rapid-acting insulin analog improves early morning fasting plasma glucose (FPG) levels in patients with type 2 diabetes. A rapid-acting insulin analog was administered at each mealtime to 40 Japanese patients with type 2 diabetes whose existing antidiabetic(More)
RESULTS — No significant differences were found in the basal level and the area under the concentration-time curve (AUC) of IRG (AUCIRG) among type 1 and type 2 diabetic patients and nondiabetic subjects. However, there was an inverse correlation between the AUCIRG and the AUC of CPR (AUCCPR) for type 1 (r 0.388, P 0.023) and type 2 (r 0.396, P 0.0001)(More)
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