Naomi S Clement

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INTRODUCTION Endometrial hyperplasia is a precancerous lesion of the endometrium, commonly presenting with uterine bleeding. If managed expectantly, it frequently progresses to endometrial carcinoma, rates of which are increasing dramatically worldwide. However, the established treatment for endometrial hyperplasia (progestogens) involves multiple side(More)
Early-onset Alzheimer's disease (EOAD) can be familial (FAD) or sporadic EOAD (sEOAD); both have a disease onset ≤65 years of age. A total of 451 sEOAD samples were screened for known causative mutations in exons 16 and 17 of the amyloid precursor protein (APP) gene. Four samples were shown to be heterozygous for 1 of 3 known causative mutations: p.A713T,(More)
Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution of these loci to AD pathogenesis, their(More)
OBJECTIVE To evaluate the current provision and outcome of community-based education (CBE) in UK medical schools. DESIGN AND DATA SOURCES An online survey of UK medical school websites and course prospectuses and a systematic review of articles from PubMed and Web of Science were conducted. Articles in the systematic review were assessed using Rossi,(More)
and Sakdapanichkul, Chidchanok and Deacon, Christopher and Zapata Erazo, Gabriela and Guerreiro, Rita and Bras, Jose and Hernandez, Dena and Singleton, Andrew and Guetta-Baranes, Tamar and Braae, Anne and Clement, Naomi and Patel, Tulsi and Brookes, Keeley and Medway, Christopher and Chappell, Sally and Mann, David M. (2016) Screening exons 16 and 17 of the(More)
We have screened sporadic early-onset Alzheimer's disease (sEOAD, n = 408) samples using the NeuroX array for known causative and predicted pathogenic variants in 16 genes linked to familial forms of neurodegeneration. We found 2 sEOAD individuals harboring a known causative variant in PARK2 known to cause early-onset Parkinson's disease; p.T240M (n = 1)(More)
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