Naomi Nezu

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Vascular contraction is induced by the activation of intracellular contractile proteins mediated through signal transduction from the outside to the inside of cells. Protein kinase C plays a crucial role in this signal transduction. It is hypothesized that protein kinase C plays a causative part in the development of vasospasm after subarachnoid hemorrhage(More)
The cross-linking of Fc receptors (FcR) on HL-60 cells inhibited the ability of recombinant IFN-gamma to induce HLA class II antigens. This appeared to be correlated with intracellular mRNA level. HL-60 lacked detectable HLA class II mRNA. IFN-gamma led to appearance of these transcripts, which were canceled by the cross-linking of FcR. Therefore,(More)
We measured functional fitness in older subjects and performed a follow-up survey for 6 years to clarify whether the level of functional fitness at a given point contributes to prediction of the subsequent occurrence of impairment of functions necessary for independent living. The longitudinal data were obtained for 391 persons aged 60 years or over, who(More)
Interferon gamma (IFN-gamma) induces HLA-DR and -DQ molecules and causes an accumulation of transcripts in HL-60 cells. Experiments were, therefore, designed to investigate the intracellular signaling molecules regulating the appearance of HLA class II molecules. The expression of HLA class II (DR and DQ) molecules induced by IFN-gamma was blocked by a(More)
We examined the signal transduction mechanism responsible for the IFN-gamma-induced HLA class II molecule expressions on glioblastoma cell lines, T98G and A172. A series of experiments demonstrated that the activation of protein kinase C (PKC) is involved in the DR and DP molecule expressions on T98G cells. In addition to the activation of PKC, calcium(More)
3H-dextran was injected into the vitreous cavity of rabbits, which had a phakic eye and an aphakic eye with the posterior capsule intact or incised. Aqueous humor was aspirated 60, 180, 360, 600, 960, or 1440 min. later and 3H-dextran was counted. The results were simulated with a two-compartment model. The diffusion constant from the vitreous body to the(More)
Small amounts of cerium-144 have been found in samples of food and animal bone obtained from Ibaraki, Japan. The highest level of radioactivity was detected in clams (Schizimi, Corbicura sp.) harvested from Hinuma Marsh. In view of the widespread occurrence of cerium-144 in tested samples, it is assumed that the presence of this radionuclide is due to(More)
A case of congenital absence of the internal carotid artery was presented in a 37-year-old male with temporal lobe epilepsy. A dilated vascular channel, which is one of the characteristics associated with the congenital absence of the internal carotid artery, can be demonstrated in the conventional contrast-enhanced CT scans. Absence of the carotid canal(More)