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Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from distinct areas of cancer and morphologically normal tissue taken from the prostates of three men. Mutations were present at high levels in morphologically normal tissue distant from the cancer, reflecting clonal expansions, and the underlying mutational processes at work(More)
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mtDNA are unclear. In this study, we analyzed somatic alterations in mtDNA from 1675 tumors. We identified 1907 somatic(More)
OBJECTIVES To investigate the relationship between prostate-specific antigen (PSA) level and tumour volume for incidental adenocarcinoma of the prostate found in cystoprostatectomy (CP) specimens, and to analyse the incidence of clinically significant prostate cancers in CP specimens and the biochemical recurrence of incidental prostate cancers on(More)
Mucinous tubular and spindle cell carcinoma (MTSCC) is a rare, distinctive renal neoplasm characterized by an admixture of cuboidal cells in tubules and sheets of spindle cells, typically with low-grade nuclei and a myxoid or mucinous background. It is characteristically of low malignant potential, and only rare metastatic cases have been reported. We(More)
BACKGROUND A better assessment of individualized prostate cancer (PrCa) risk is needed to improve screening. The use of the prostate-specific antigen (PSA) level for screening in the general population has limitations and is not currently advocated. Approximately 100 common single nucleotide polymorphisms (SNPs) have been identified that are associated with(More)
BACKGROUND We aimed to evaluate the trends in pathologic outcomes of clinically localized prostate cancer treated with radical prostatectomy prior to and after national guidelines placing active surveillance as the primary management in men with low-risk prostate cancer. Further, we examined whether there was a coincident change in the proportion of men(More)
For further information, please contact: Prof. Josep Lloreta-Trull (local organizer) Department of Pathology Hospital del Mar-IMAS-IMIM Universitat Pumpeu Fabra Passeig Marítim 25–29, 08003-Barcelona, Spain Tel.: +34 93 248 30 31, Fax: +34 93 248 31 31 E-mail: jlloreta@imas.imim.es or enter the course website http://www.tilesa.es/eurocellpath04/ 10–14 May(More)
. The 10 International Congress on Oral Cancer is supported by the World Health Organization, the International Union Against Cancer, the International Congress on Oral Cancer, the Hellenic Association for the Research and Treatment of Oral Cancer, and the Hellenic Cancer Society . The Congress theme is The Oral Cancer Patient: the anthropocentric approach(More)