Naoki Shibata

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Although the sex-determining gene Sry has been identified in mammals, no comparable genes have been found in non-mammalian vertebrates. Here, we used recombinant breakpoint analysis to restrict the sex-determining region in medaka fish (Oryzias latipes) to a 530-kilobase (kb) stretch of the Y chromosome. Deletion analysis of the Y chromosome of a congenic(More)
The Wnt signaling pathway controls numerous cell fates in animal development and is also a major cancer pathway. Dishevelled (Dvl) transduces the Wnt signal by interacting with the cytoplasmic Axin complex. Dvl and Axin each contain a DIX domain whose molecular properties and structure are unknown. Here, we demonstrate that the DIX domain of Dvl2 mediates(More)
In this paper, we propose a simulator for facilitating reliable and inexpensive development of ubiquitous applications where each application software controls a lot of information appliances based on the state of external environment, user’s contexts and preferences. The proposed simulator realistically reproduces behavior of application software on(More)
The recent discovery of the DMY gene (DM domain gene on Y chromosome and one of the DMRT1 family genes) as a key determinant of male development in the medaka (Oryzias latipes) has led to its designation as the prime candidate gene for sex-determination in this species. This study focused on the sites and pattern of expression of DMY and DMRT1 genes during(More)
In this paper, we propose a personal navigation system for tourism called P-Tour. When a tourist specifies multiple destinations with relative importance and restrictions on arrival/staying time, P-Tour computes the nearly best schedule to visit part of those destinations. In addition to the map-based navigation, P-Tour provides temporal guidance according(More)
In this paper, we performed a comparative study in two research domains in order to develop a method of detecting emerging knowledge domains. The selected domains are research on gallium nitride (GaN) and research on complex networks, which represent recent examples of innovative research. We divided citation networks into clusters using the topological(More)
a Innovation Policy Research Center, School of Engineering, The University of Tokyo, 2-11-16 Yayoi, Bunkyo Ward, Tokyo 113-8656, Japan b Department of Project Management, Faculty of Social Systems Science, Chiba Institute of Technology, 2-17-1 Tsudanuma, Narashino, Chiba Prefecture 275-0016, Japan c Todai Policy Alternatives Research Institute, The(More)
In this paper, we propose a method for cars to autonomously and cooperatively collect traffic jam statistics to estimate arrival time to destination for each car using inter-vehicle communication. In the method, the target geographical region is divided into areas, and each car measures time to pass through each area. Traffic information is collected by(More)
Foxl2 is a member of the winged helix/forkhead family of transcription factors and is known to be involved in ovarian development in some vertebrates. To address the role of Foxl2 in ovarian differentiation in medaka, we isolated Foxl2 cDNA and analyzed its expression patterns during sex differentiation. Expression of Foxl2 started in somatic cells(More)
Dax1 is a member of an unusual orphan nuclear receptor family, and is known to regulate P450arom in mammals and is involved in sex differentiation in some vertebrates. To investigate whether Dax1 is involved in the regulation of the steroidogenic pathway for estrogen biosynthesis in medaka ovarian follicles, we isolated Dax1 cDNA from adult medaka ovaries(More)