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Identification of Cytochrome P450s Required for Fumitremorgin Biosynthesis in Aspergillus fumigatus
TLDR
Missing links in the fumitremorgin biosynthetic pathway have been elucidated as crucial processes for the inhibitory activity of fum it Remorgin C against breast cancer resistance protein (BCRP).
A Point Mutation in ftmD Blocks the Fumitremorgin Biosynthetic Pathway in Aspergillus fumigatus Strain Af293
TLDR
Biochemical analysis indicated that FtmD is a methyltransferase that catalyzes the conversion of 6-hydroxytryprostatin B into try Prostatin A, resulting in blockage of the FTM pathway in A. fumigatus Af293.
Wakodecalines A and B, new decaline metabolites isolated from a fungus Pyrenochaetopsis sp. RK10-F058
TLDR
Two new decaline metabolites, wakodecalines A and B, were isolated from a fungus by screening for structurally unique metabolites using LC/MS analysis and showed moderate antimalarial activity against the Plasmodium falciparum 3D7 strain.
Temperature during conidiation affects stress tolerance, pigmentation, and trypacidin accumulation in the conidia of the airborne pathogen Aspergillus fumigatus
TLDR
Data show that the environmental temperature during conidiation affects conidial properties such as stress tolerance, pigmentation, and mycotoxin accumulation.
Genetic Safeguard against Mycotoxin Cyclopiazonic Acid Production in Aspergillus oryzae
TLDR
It is demonstrated that an A. oryzae‐specific gene—cpaH—mediates the conversion of CPA into the less toxic 2‐oxocyclopiazonic acid, a new analogue of Cpa, which reflects the relationship of the two species.
Control of the Stereochemical Course of [4+2] Cycloaddition during trans-Decalin Formation by Fsa2-Family Enzymes.
TLDR
A decalin skeleton with an unnatural configuration was successfully constructed by gene replacement of phm7 with fsa2, thus demonstrating enzymatic control of all stereochemistry in the [4+2] cycloaddition.
Gene Disruption and Biochemical Characterization of Verruculogen Synthase of Aspergillus fumigatus
TLDR
The ftm cluster, which is responsible for fumitremorgin production in Aspergillus fumigatus, is one of the secondary metabolite biosynthetic gene clusters whose products have been identified based on genomic information and a knockout experiment and a kinetic analysis are performed to clarify the function of FtmF as an endoperoxidation catalyst.
Biosynthesis and Structure-Activity Relationship Studies of Okaramines That Target Insect Glutamate-Gated Chloride Channels.
TLDR
Analysis of the structure-activity relationships ofOkaramines collected from the fungal cultures revealed that 1,4-dihydroazocine and N-aliphatic group attached to the indole were crucial for GluCl-activating activity, providing insights into further derivatization of the complex structure of okaramines in order to facilitate the development of new insecticides.
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