Naohiro Fumoto

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Mutations of the leucine-rich glioma-inactivated 1 (LGI1) gene cause an autosomal dominant partial epilepsy with auditory features also known as autosomal-dominant lateral temporal lobe epilepsy. LGI1 is also the main antigen present in sera and cerebrospinal fluids of patients with limbic encephalitis and seizures, highlighting its importance in a spectrum(More)
Mutations in the leucine-rich, glioma inactivated 1 (LGI1) gene have been identified in patients with autosomal dominant lateral temporal lobe epilepsy (ADLTE). We previously reported that Lgi1 mutant rats, carrying a missense mutation (L385R) generated by gene-driven N-ethyl-N-nitrosourea (ENU) mutagenesis, showed generalized tonic-clonic seizures (GTCS)(More)
A 70-year-old man was admitted to our hospital with visual loss, dysesthesia, gait disturbance, and urinary retention. A pacemaker was implanted 1 year ago for atrioventricular conduction block. Neurologic examination revealed mild cognitive impairment, near blindness with vitreous opacity, diffuse muscle weakness, loss of all sensory modalities with(More)
Sixty male subjects were divided into three equal groups, one control and the other two experimental. The experimental groups were given two tracking tasks in different orders. The tasks were given by distributed practice. One tracking task consisted of far and near movements at short regular intervals, while the other was of irregular longer intervals.(More)
Eight subjects were given overlearning of a pursuit tracking task twice which they experienced once either half or one year previously. Distributed practice was employed in the present experiments. Finger skin blood flow (SBF) and pulse rate (PR) were measured throughout the experiments. SBF was smaller during trials and during intertrial rests than during(More)
Eight subjects were given a pursuit tracking task (Exp. I), a continuous task involving the adding of digits (Exp. II), and the Uchida-Kraepelin psychodiagnostic test (Exp. III). Experiments I and II employed distributed practice. Finger Skin Blood Flow (SBF) and Pulse Rate (PR) were measured during the experiments. It was found that SBF was smaller during(More)
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