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The liver is the main organ of drug metabolism, but the expression and induction by xenobiotics of drug-metabolizing enzymes is also often observed in extrahepatic tissues. Recently, we reported that lipophilic cytochrome P450 inducers, beta-naphthoflavone (BNF), phenobarbital, and dexamethasone, induced CYP1, CYP2B, and CYP3A enzymes, respectively, in rat(More)
Lipophilic environmental pollutants are often stored in adipose tissues after exposure. These compounds have been well studied in terms of their cell toxicity in organs such as liver and kidney, and their xenoestrogenic action on reproductive tissues as endocrine disruptors. However, the effects of these chemicals on the depot, adipose tissue, have not been(More)
The ip coadministration of 200 mg/kg butylated hydroxyanisole (BHA) with a subtoxic dose (200 mg/kg) of butylated hydroxytoluene (BHT) enhanced the lung toxicity of BHT in mice. BHA coadministration significantly increased the radioactivity covalently bound to lung macromolecules at 4-8 hr after [14C]BHT. The area under the concentration versus time curve(More)
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