Nantia Iakovidou

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5 7 a r t i c l e i n f o 8 a b s t r a c t 13 Available online xxxx 14 Link prediction in protein–protein interaction networks (PPINs) is an important task in 15 biology, since the vast majority of biological functions involve such protein interactions. Link 16 prediction is also important for online social networks (OSNs), which provide predictions 17(More)
— An increasing number of observations support the hypothesis that the vast majority of biological functions involve interactions between proteins and that the complexity of living systems arises as a result of such interactions. In this paper we apply a multiway spectral clustering technique to protein-protein interaction networks to perform accurate link(More)
Object oriented dependable server applications often rely on fault tolerance schemes, which are comprised of different replication policies for the constituent objects (composite replication schemes). This paper introduces a simulation-based evaluation approach for quantifying the tradeoffs between fault-tolerance overhead and fault tolerance effectiveness(More)
This article presents in detail our novel proposed methodology for detecting similarity between or among three dimensional protein structures. The innovation of our algorithm relies on the fact that during the similarity process, it has the ability to combine many attributes together and fulfill lots of preconditions, which are extensively discussed(More)
Protein structure similarity is one of the most important aims pursued by bioinformatics and structural biology, nowadays. Although quite a few similarity methods have been proposed lately, yet fresh algorithms that fulfill new preconditions are needed to serve this purpose. In this paper, we provide a new similarity measure for 3D protein structures that(More)
The vast majority of existing methods for ranking gene datasets, do not include or take into account in their exported results other information that might accompany the genes, such as specie or terms. Given a higher order biological data set, we propose a methodology based on multilinear algebra for ranking genes across multiple dimensions. We apply(More)
Retrieval queries in microarray databases can rank genes according either to their similarity by detecting functionally related genes, or to their importance by detecting genes with significant regulation role. Although both rankings are useful, they can be contradicting. For instance, similar highly ranked genes may have low importance and vice versa.(More)
In distributed object systems, application level fault tolerance is often attained by appropriate object replication policies. These policies aim at increasing the exhibited service availability by masking potential faults that do not recur after recovery. Existing middleware support infrastructures allow customizing object replication properties. However,(More)
Object oriented applications and services are composed of a number of objects with instances, which interact to accomplish common goals. Fault tolerance is attained via application transparent replication policies for masking faults that do not recur after recovery. Recently, we realized the advent of a number of middleware infrastructures and services,(More)
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