Nanne Klaas de Boer

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The overall metabolic state of an individual is reflected by emitted volatile organic compounds (VOCs), which are gaseous carbon-based chemicals. In this review, we will describe the potential of VOCs as fully noninvasive markers for the detection of neoplastic lesions of the colon. VOCs are detected by our sensory olfactory nerves and form the molecular(More)
BACKGROUND & AIMS Ipilimumab, a monoclonal antibody against cytotoxic T-lymphocyte-associated antigen-4, is a treatment for metastatic melanoma that can induce immune-related adverse effects, such as enterocolitis. We aimed to characterize the clinical, endoscopic, and histologic features of ipilimumab-induced colitis and evaluate the efficacy of therapy(More)
BACKGROUND AND AIMS Acute optic neuritis [ON] is an inflammatory condition affecting the optic nerve. Clinicians should suspect optic neuritis in cases of painful and rapidly progressive loss of central visual field. This condition may be associated with a multitude of diseases, and mostly with multiple sclerosis [MS] where it may present as an initial(More)
Ipilimumab is a fully humanized immunoglobulin antibody directed against the cytotoxic T-lymphocyte-associated antigen-4. Administration of ipilimumab leads to induction of T-cell proliferation andmay cause tumor regression and necrosis. Studies in patients with melanoma have shown efficacy and survival benefit.1 Adverse and unwanted autoimmune phenomena(More)
igure 1 Endoscopic image of the sole showing multiple lightrown to black coloured moles. Long term use of thiopurines in the treatment of inflammatory bowel disease (IBD) is associated with the development of non-melanoma skin cancer. Here we present a patient who developed unusual skin abnormalities during azathioprine administration. A 22-year-old woman(More)
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