Nanne Aben

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Graham R. Bignell1
Tinghu Zhang1
Theo A. Knijnenburg1
1Graham R. Bignell
1Tinghu Zhang
1Theo A. Knijnenburg
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MOTIVATION Clinical response to anti-cancer drugs varies between patients. A large portion of this variation can be explained by differences in molecular features, such as mutation status, copy number alterations, methylation and gene expression profiles. We show that the classic approach for combining these molecular features (Elastic Net regression on all(More)
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature of cancer. Using this information to guide the development and application of therapies in the clinic is challenging. Here, we report how cancer-driven alterations identified in 11,289 tumors from 29 tissues (integrating somatic mutations, copy number(More)
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