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The ob gene product, leptin, is an important circulating signal for the regulation of body weight. To identify high affinity leptin-binding sites, we generated a series of leptin-alkaline phosphatase (AP) fusion proteins as well as [125I]leptin. After a binding survey of cell lines and tissues, we identified leptin-binding sites in the mouse choroid plexus.(More)
OBJECTIVE The present study was conducted to characterize the expression of the cysteine protease legumain in murine and human atherosclerotic tissues, and to explore the molecular mechanisms by which legumain may contribute to the pathophysiology of atherosclerosis. METHODS AND RESULTS Using microarray analysis, legumain mRNA expression was found to(More)
We have identified two lung carcinoma cell lines, A549 and Calu-l, expressing low levels of the macrophage colony-stimulating factor (CSF1) receptor (CSF-1 R), encoded by the c-fms oncogene. The effect of CSF1 on the invasive potential of these CSF-1 R-positive tumor cell lines and on two other CSF-1 R-bearing cell lines, the BT-20 breast carcinoma cell(More)
We have identified two lung carcinoma cell lines, A549 and Calu-l, expressing low levels of the macrophage colony-stimulating factor (CSF1) receptor (CSF-1 R), encoded by the c-fms oncogene. The effect of CSF1 on the invasive potential of these CSF-1 R-positive tumor cell lines and on two other CSF-1 R-bearing cell lines, the BT-20 breast carcinoma cell(More)
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