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Early to mid-adolescence is an important developmental period for subcortical brain maturation, but longitudinal studies of these neurodevelopmental changes are lacking. The present study acquired repeated magnetic resonance images from 60 adolescent subjects (28 female) at ages 12.5 and 16.5 years to map changes in subcortical structure volumes. Automated(More)
OBJECTIVE The authors sought to investigate whether the structural development of limbic, striatal, and prefrontal regions that are critically implicated in the pathophysiology of depression is associated with adolescent-onset depression. METHOD In a longitudinal design, a risk enriched community sample of 86 adolescents (41 of them female) who had no(More)
Visuomotor adaptation to left-shifting prisms can affect performance for a variety of tasks in neurologically intact (normal) participants. This study examined whether visuomotor adaptation affects performance on the greyscales task in normal participants. Forty-two normal participants completed a greyscales task before and after adaptation to either:(More)
This study examined whether development of two forms of cognitive control (proactive and reactive) between early and midadolescence was associated with the onset of major depressive disorder (MDD) during the same period and if it prospectively predicted MDD onset between mid- and late adolescence. Adolescents (N = 165) completed 3 waves of assessments, at(More)
INTRODUCTION Tobacco use among school children is becoming a serious problem in developing countries. The early age of initiation underscores the urgent need to intervene and protect this vulnerable group from becoming victims of this addiction. AIM To assess the knowledge, attitudes, and practices about tobacco use among 13-15 year old school children of(More)
Autism spectrum disorders denote a series of lifelong neurodevelopmental conditions characterized by an impaired social communication profile and often repetitive, stereotyped behavior. Recent years have seen the complex genetic architecture of the disease being progressively unraveled with advancements in gene finding technology and next generation(More)
Individuals with hemiplegia have difficulty planning movements, which may stem from deficits in motor imagery ability. We explored motor imagery ability in three groups of 21 children, aged 8-12 years: children with hemiplegia; children with developmental coordination disorder (DCD); and a comparison group. They completed two tasks requiring laterality(More)
OBJECTIVE The hippocampus and amygdala have received much attention with regard to the deleterious effects of childhood maltreatment. However, it is not known if and when these effects emerge during adolescence and whether comorbid psychopathology is more likely to explain these effects. This study investigated whether childhood maltreatment was associated(More)
OBJECTIVE The objective of this study was to follow up a cohort of subjects who completed detoxification treatment and a deaddiction program based on the Alcoholics Anonymous (AA) model. The factors associated with complete abstinence were investigated. METHOD Patients (187 men) admitted consecutively to an addiction facility, who fulfilled the DSM-IV(More)
Little work has been conducted that examines the effects of positive environmental experiences on brain development to date. The aim of this study was to prospectively investigate the effects of positive (warm and supportive) maternal behavior on structural brain development during adolescence, using longitudinal structural MRI. Participants were 188 (92(More)