Nandita Sinha

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BACKGROUND It has been suggested that peroxisome proliferator-activated receptor (PPAR)-gamma ligands reduce the development of atherosclerosis and myocardial ischemia-reperfusion injury; both of these phenomena are associated with platelet activation. We postulated that PPAR-gamma activation would inhibit platelet activation and intra-arterial thrombus(More)
Vitamin D is a steroid hormone with canonical roles in calcium metabolism and bone modeling. However, in recent years there has been a growing body of literature presenting associations between vitamin D levels and a variety of disease processes, including metabolic disorders such as diabetes and prediabetes and autoimmune conditions such as thyroid(More)
A QSAR based predictive model of hERG activity in terms of 'global descriptors' has been developed and evaluated. The QSAR was developed by training 77 compounds covering a wide range of activities and was validated based on an external 'test set' of 80 compounds using neural network method. Statistical parameters and examination of enrichment factor(More)
Simultaneous oscillations of 1318.8nm, 1320.0nm, 1332.6nm, 1335.0nm, 1338.2nm and 1339.0nm in a side, pulsed-diode-laser-array pumped Nd:YAG laser is realized for both free running and Q-switched operation. An average power of 1.1W is obtained for an absorbed pump power of 7.1W with an effective optical slope efficiency of 33%. The difference frequency(More)
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