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483 H ip dysplasia in dogs is a polygenic disease characterized by hip instability that results in secondary osteoarthritis, lameness, and physical disability. 1 Medical and surgical management of the condition have economic and emotional impacts on dog owners and breeders. As a complex trait, HD is caused by genetic and environmental factors that influence(More)
BACKGROUND Canine hip dysplasia (HD) is a common polygenic trait characterized by hip malformation that results in osteoarthritis (OA). The condition in dogs is very similar to developmental dysplasia of the human hip which also leads to OA. METHODOLOGY/PRINCIPAL FINDINGS A total of 721 dogs, including both an association and linkage population, were(More)
The domestic dog is becoming an increasingly valuable model species in medical genetics, showing particular promise to advance our understanding of cancer and orthopaedic disease. Here we undertake the largest canine genome-wide association study to date, with a panel of over 4,200 dogs genotyped at 180,000 markers, to accelerate mapping efforts. For(More)
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