Nancy Olashaw

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Histone deacetylase (HDAC) inhibitors inhibit the proliferation of transformed cells in vitro, restrain tumor growth in animals, and are currently being actively exploited as potential anticancer agents. To identify gene targets of the HDAC inhibitor trichostatin A (TSA), we compared the gene expression profiles of BALB/c-3T3 cells treated with or without(More)
Platelet-derived growth factor (PDGF) has been proposed to initiate the cell-cycle traverse of density-arrested BALB/c-3T3 cells by rendering quiescent cells 'competent' to respond to 'progression' factors contained in platelet-poor plasma (PPP). PDGF-treated cells remain competent for many hours following PDGF removal; subsequent addition of PPP triggers(More)
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